Internationally, there is no standard treatment for patients with ISSHL but current therapeutic approaches are mainly focused on different forms of application of corticosteroids. Antivirals, thrombolytics, vasodilators, and rheologics seem to have no effect. Because of the unexplained cause, many therapies have been tried. The incidence is estimated to be between 8–400/100,000 cases. Prednisolone treatment combined with NAC resulted in better hearing outcomes in patients with ISSHL than treatment without NAC.Īn idiopathic sudden sensorineural hearing loss (ISSHL) is a sudden onset, usually unilateral, cochlear sensorineural hearing loss of ≥ 30 dB within < 3 days in at least 3 contiguous frequencies without an identifiable cause. In multivariable analysis on Japan classification in 10-tone PTA including all significant factors from univariate analysis, negative prognosis of hearing recovery were age > median (odds ratio 1.648 95% confidence interval 1.139–2.385 p = 0.008), diseased opposite ear (OR 3.049 CI 2.157–4.310 p < 0.001), pantonal ISSHL (OR 1.891 CI 1.309–2.732 p = 0.001) and prednisolone alone without NAC treatment (OR 1.862 CI 1.200–2.887 p = 0.005). In univariate analysis, treatment with prednisolone and NAC was associated with a positive prognosis of hearing recovery in the Japan classification in 10-tone PTA. Mean initial ISSHL and hearing gain after treatment in 10-tone pure tone audiometry (PTA) were 54.8 ± 34.5 dB and 15.2 ± 21.2 dB, respectively. Univariate and multivariable analysis were performed to identify independent factors regarding negative prognosis of hearing recovery. 663 patients received NAC administration in addition to standard tapered prednisolone treatment. Methodsħ93 patients (median age 60 years 50.9% women) with a new diagnosis of ISSHL from 2009 to 2015 were included in the study. This is a retrospective monocentric study investing the impact of adding N-acetylcysteine (NAC) to prednisolone treatment on patients with ISSHL at a tertiary university otorhinolaryngology department. The results of the data that you use with this tool are displayed in a viewer together with graphs and charts that you can copy and paste into other programs, or export in PDF or DOC format to print or save for future use.Internationally, corticosteroids are still the mainstay treatment for patients with idiopathic sudden sensorineural hearing loss (ISSHL). IBM SPSS Statistics Base is also capable of detecting fraud to minimize your risk, and understands which characteristics customers relate with your business's brand. It incorporates a comprehensive menu dedicated to modifying files, risk analyses, client identification, cost/benefit analyses, and trend analyses for better planning your organization's strategy and future manufacturing processes. The data editor is another standout feature in IBM SPSS Statistics Base. All of your analyses will be run using dialog boxes from an interface that doesn't present any problems when dealing with large amounts of data and variables. It can analyze your data and create graphs and charts to display it quite easily. This tool includes a wide array of features for easily accessing and managing large amounts of data. It has quality prediction models and analysis methods. If you're looking for a statistics program capable of doing everything you need for your business or research, IBM SPSS Statistics Base may be just what you need.
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